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| Product Category: | Knockdown Validated Polyclonal Antibody |
| Synonyms: | NEDD4 E3 Ubiquitin Protein Ligase; Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase; Cell Proliferation-Inducing Gene 53 Protein; HECT-Type E3 Ubiquitin Transferase NEDD4; E3 Ubiquitin-Protein Ligase NEDD4; Receptor-Potentiating Factor 1; NEDD4-1; Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4; Neural Precursor Cell Expressed, Developmentally Down-Regulated 4; EC 2.3.2.26; KIAA0093; EC 6.3.2; NEDD-4; RPF1 |
| UniProt Entry: | P46934 |
| NCBI Gene Entry: | 4734 |
| Molecular Weight: | 115 kDa |
| Clonality: | Rabbit polyclonal antibody |
| Species Reactivity: | Human |
| Applications: | IC |
| Recommended Dilution: | IC 1:50 |
| Immunogen: | Recombinant fragment of human NEDD4 |
| Isotype: | Rabbit IgG |
| Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
| Storage: | At –20°C |
| Background: | NEDD4 gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. |
| Documents: | Please contact us to request the manual |
